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Figure 2 | Journal of Biomedical Science

Figure 2

From: A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system

Figure 2

Effect of daily systemic injections of donepezil (0, 0.5, 1, 1.5 mg/kg, ip) on tolerance to the analgesic effect of morphine. Each bar represents the mean of percentage of maximal possible effect (%MPE) ± sem for eight rats. Student’s t-test was used to analysis the differences of %MPE between saline and treated animals every day also it was utilized for comparison of the day of tolerance establishment in control or treatment groups. *P < 0.05; **P < 0.01; ***P < 0.001 when compared with the saline group. a = P < 0.001 when compared with the control group. Arrow represents the day of morphine tolerance. M = Morphine; DPZ = Donepezil.

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