Study sections | Treatment groups (n = 8 per group) | |
---|---|---|
Behavioral evaluation | Saline (1 ml/kg, ip) | |
Morphine (10 mg/kg, ip) + Donepezil (0, 0.5, 1, 1.5 mg/kg, ip) | ||
The most effective dose of Donepezil (1.5 mg/kg, ip) for 14 days | ||
Groups for dose–response curves: | Saline (1 ml/kg, ip) | |
Animals received opposite treatments for 14 days, on 15th day, in separate groups logarithmic doses of morphine (1 or 100 mg/kg, ip) were administered to generate analgesic dose–response curves | Morphine (10 mg/kg, ip) + donepezil (0, 1.5 mg/kg, ip) | |
Morphine (10 mg/kg, ip) + MK801(0.1 mg/kg, ip) | ||
Immunohistological evaluation | Saline (1 ml/kg, ip) for 14 days | |
Morphine (10 mg/kg, ip) + Donepezil (0, 0.5, 1, 1.5 mg/kg, ip) for 14 days | ||
The most effective dose of Donepezil (1.5 mg/kg, ip) for 14 days | ||
Morphine (10 mg/kg, ip) + MK-801(0.1 mg/kg) for 14 days |