Skip to main content

Table 1 The experimental groups for behavioral & immunohistological evaluations

From: A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system

Study sections Treatment groups (n = 8 per group)
Behavioral evaluation Saline (1 ml/kg, ip)
Morphine (10 mg/kg, ip) + Donepezil (0, 0.5, 1, 1.5 mg/kg, ip)
The most effective dose of Donepezil (1.5 mg/kg, ip) for 14 days
Groups for dose–response curves: Saline (1 ml/kg, ip)
Animals received opposite treatments for 14 days, on 15th day, in separate groups logarithmic doses of morphine (1 or 100 mg/kg, ip) were administered to generate analgesic dose–response curves Morphine (10 mg/kg, ip) + donepezil (0, 1.5 mg/kg, ip)
Morphine (10 mg/kg, ip) + MK801(0.1 mg/kg, ip)
Immunohistological evaluation Saline (1 ml/kg, ip) for 14 days
Morphine (10 mg/kg, ip) + Donepezil (0, 0.5, 1, 1.5 mg/kg, ip) for 14 days
The most effective dose of Donepezil (1.5 mg/kg, ip) for 14 days
Morphine (10 mg/kg, ip) + MK-801(0.1 mg/kg) for 14 days