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Table 1 The experimental groups for behavioral & immunohistological evaluations

From: A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system

Study sections

Treatment groups (n = 8 per group)

Behavioral evaluation

Saline (1 ml/kg, ip)

Morphine (10 mg/kg, ip) + Donepezil (0, 0.5, 1, 1.5 mg/kg, ip)

The most effective dose of Donepezil (1.5 mg/kg, ip) for 14 days

Groups for dose–response curves:

Saline (1 ml/kg, ip)

Animals received opposite treatments for 14 days, on 15th day, in separate groups logarithmic doses of morphine (1 or 100 mg/kg, ip) were administered to generate analgesic dose–response curves

Morphine (10 mg/kg, ip) + donepezil (0, 1.5 mg/kg, ip)

Morphine (10 mg/kg, ip) + MK801(0.1 mg/kg, ip)

Immunohistological evaluation

Saline (1 ml/kg, ip) for 14 days

Morphine (10 mg/kg, ip) + Donepezil (0, 0.5, 1, 1.5 mg/kg, ip) for 14 days

The most effective dose of Donepezil (1.5 mg/kg, ip) for 14 days

Morphine (10 mg/kg, ip) + MK-801(0.1 mg/kg) for 14 days