Figure 7From: Activation of neutral-sphingomyelinase, MAPKs, and p75 NTR-mediating caffeic acid phenethyl ester–induced apoptosis in C6 glioma cellsSchematic presentation of the signaling pathways involved in CAPE-induced apoptotic pathway in C6 glioma cells. The effect of CAPE on the MAPKs signaling triggering activation of NGF/p75NTR/JNK and p53 dependent apoptosis, which induces the N-SMase/ceramide up-regulation and increases an apoptosis cascade.Back to article page