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Table 1 ED 50 values, in mg/kg ± SEM, for the antinociceptive activity of intraperitoneal administration of fentanyl, methadone, morphine and tramadol without and with naltrexone (NTX) 1 mg/kg i.p., naltrindole (NTI) 2 mg/kg i.p. and nor-BNI 3 mg/kg i.p. in the writhing test of mice

From: Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain

Drug

ED50 ±SEM

 

Alone

+ NTX

+ NTI

+ nor-BNI

 

(n = 24)

(n = 24)

(n = 24)

(n = 24)

Fentanyl

0.016 ± 0.002

3.04 ± 0.38*

2.89 ± 0.42

0.017 ± 0.003

Methadone

0.085 ± 0.005

1.45 ± 0.15*

0.065 ± 0.008

0.081 ± 0.006

Morphine

0.125 ± 0.019

2.20 ± 0.36*

1.56 ± 0.15*

0.097 ± 0.14

Tramadol

3.904 ± 0.495

4.24 ± 0.80

2.98 ± 0.35

2.86 ± 0.65

  1. All results between opioids alone are significant (P < 0.05). *P < 0.05 comparing with ED50 alone. n = number of animals used in each drug determination.
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Journal of Biomedical Science

ISSN: 1423-0127