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Table 2 ED 50 values, in mg/kg ± SEM, for the antinociceptive activity of intraperitoneal administration of fentanyl, methadone, morphine and tramadol without and with naltrexone (NTX) 1 mg/kg i.p., naltrindole (NTI) 2 mg/kg i.p. and nor-BNI 3 mg/kg i.p. in the hot plate test of mice

From: Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain

Drug

ED50 ±SEM

 

Alone

+ NTX

+ NTI

+ nor-BNI

 

(n = 24)

(n = 24)

(n = 24)

(n = 24)

Fentanyl

0.040 ± 0.002

2.41 ± 0.25*

2.51 ± 0.25*

0.037 ± 0.003

Methadone

0.24 ± 0.015

0.58 ± 0.08*

0.011 ± 0.008*

0.022 ± 0.006

Morphine

1.94 ± 0.084

3.82 ± 0.36*

3.56 ± 0.15*

2.31 ± 0.44

Tramadol

30.53 ± 0.98

34.74 ± 1.25*

32.14 ± 0.53

29.75 ± 2.58

  1. All results between opioids alone are significant (P < 0.05). *P < 0.05 when comparing con opioids alone.
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Journal of Biomedical Science

ISSN: 1423-0127