Table 4 Theoretical and experimental ED 50 values with 95% CL, and interaction index for the antinociceptive activity of the intraperitoneal coadministration of morphine with methadone, morphine with fentanyl, and morphine with tramadol, fentanyl with methadone, methadone with tramadol, and fentanyl with tramadol in the hot plate test of mice
Drugs | ED50(95% CL) | Interaction index | |
|---|---|---|---|
Theoretical | Experimental | ||
Morphine/methadone | 1.09 (0.14-0.07) | 0.58*(0.7-0.02) | 0.532 |
Methadone/fentanyl | 0.14(0.28-0.06) | 0.08* (0.10-0.01) | 0.571 |
Morphine/fentanyl | 0.99(1.14-0.85) | 0.60* (0.78-0.20) | 0.606 |
Morphine/tramadol | 16.23(18.26-14.41) | 11.20* (12.71-9.64) | 0.690 |
Methadone/tramadol | 15.38(1740–13.58) | 15.51 (16.85-12.62) | 1.008 |
Fentanyl/tramadol | 15.28(15.45-15.11) | 16.00 (16.92-15.012) | 1.047 |