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Table 1 The levels of biosynthetic metabolites

From: ADI1, a methionine salvage pathway enzyme, is required for Drosophila fecundity

 

(ppm)

Metabolites

Control

Control + Met

Dadi1-74

Dadi1-74 + Met

SAM

6.733 ± 1.149

6.217 ± 1.295

1.604 ± 0.535

3.014 ± 1.061

Spermidine

0.647 ± 0.188

0.647 ± 0.241

0.422 ± 0.087

0.262 ± 0.134

MTA

0.013 ± 0.003

0.014 ± 0.002

0.010 ± 0.001

0.014 ± 0.002

Methionine sulfoxide

15.852 ± 3.377

46.482 ± 1.972

0.392 ± 0.206

11.949 ± 1.794

SAH

0.028 ± 0.009

0.017 ± 0.005

0.023 ± 0.011

0.017 ± 0.004

Homocysteine

0.083 ± 0.019

0.049 ± 0.014

0.051 ± 0.004

0.035 ± 0.005

Cysteine

0.261 ± 0.063

0.230 ± 0.075

0.149 ± 0.029

0.119 ± 0.021

Serine

11.839 ± 2.942

10.746 ± 0.643

11.450 ± 0.894

10.374 ± 1.722

  1. The concentrations of metabolites were analyzed by UPLC-MS/MS and normalized with phenylalanine.
  2. The unit of concentration is ppm (parts per million).