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Table 1 Hematological analysis of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

  Males Females
Parameter Homozygous mutants Heterozygous mutants Homozygous mutants Heterozygous mutants
WBC (103/μl) 8.4 ± 0.9a 6.4 ± 0.3 7.0 ± 0.2 6.8 ± 0.5
RBC (106/μl) 8.8 ± 0.1a 9.1 ± 0.1 9.0 ± 0.2 9.0 ± 0.1
PLT (103/μl) 680 ± 14c 760 ± 12 671 ± 21 704 ± 22
HGB (g/dl) 14.2 ± 0.2b 14.9 ± 0.1 14.8 ± 0.3 14.5 ± 0.2
HCT (%) 43.5 ± 0.5b 46.1 ± 0.4 45.3 ± 0.8 45.0 ± 0.4
MCV (fl) 49.5 ± 0.2b 50.4 ± 0.2 50.4 ± 0.3 50.1 ± 0.2
MCH (pg) 16.1 ± 0.1 16.3 ± 0.1 16.4 ± 0.1 16.1 ± 0.1
MCHC (g/dl) 32.6 ± 0.2 32.3 ± 0.1 32.7 ± 0.2 32.3 ± 0.1
  1. WBC, white blood cell count; RBC, red blood cell count; PLT, platelet count; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.
  2. 22-week-old mice were tested. No. per genotype and sex: n = 8–10. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01, cP < 0.001.