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Table 1 Hematological analysis of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

 

Males

Females

Parameter

Homozygous mutants

Heterozygous mutants

Homozygous mutants

Heterozygous mutants

WBC (103/μl)

8.4 ± 0.9a

6.4 ± 0.3

7.0 ± 0.2

6.8 ± 0.5

RBC (106/μl)

8.8 ± 0.1a

9.1 ± 0.1

9.0 ± 0.2

9.0 ± 0.1

PLT (103/μl)

680 ± 14c

760 ± 12

671 ± 21

704 ± 22

HGB (g/dl)

14.2 ± 0.2b

14.9 ± 0.1

14.8 ± 0.3

14.5 ± 0.2

HCT (%)

43.5 ± 0.5b

46.1 ± 0.4

45.3 ± 0.8

45.0 ± 0.4

MCV (fl)

49.5 ± 0.2b

50.4 ± 0.2

50.4 ± 0.3

50.1 ± 0.2

MCH (pg)

16.1 ± 0.1

16.3 ± 0.1

16.4 ± 0.1

16.1 ± 0.1

MCHC (g/dl)

32.6 ± 0.2

32.3 ± 0.1

32.7 ± 0.2

32.3 ± 0.1

  1. WBC, white blood cell count; RBC, red blood cell count; PLT, platelet count; HGB, hemoglobin; HCT, hematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration.
  2. 22-week-old mice were tested. No. per genotype and sex: n = 8–10. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01, cP < 0.001.