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Table 4 Analysis of energy metabolism of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

  Males Females  
Parameter Homozygous mutants Heterozygous mutants Homozygous mutants Heterozygous mutants t-test
Body weight (g) 33.0 ± 0.4 40.0 ± 1.1 31.7 ± 1.3 36.2 ± 1.3 c
Rectal body temperature (°C) 36.2 ± 0.04 36.3 ± 0.1 36.7 ± 0.1 36.6 ± 0.1  
Food intake (g/day) 3.7 ± 0.2 4.1 ± 0.1 3.9 ± 0.2 3.9 ± 0.1  
Energy uptake (kJ/day) 66.2 ± 4.2 72.6 ± 1.6 69.9 ± 4.0 70.1 ± 2.0  
Energy uptake / body weight (kJ/g/day) 2.0 ± 0.1 1.8 ± 0.1 2.2 ± 0.1 2.0 ± 0.1 a
Feces production (g/day) 0.91 ± 0.04 0.91 ± 0.05 0.81 ± 0.08 0.93 ± 0.02  
Energy content of feces (kJ/g) 15.3 ± 0.1 15.4 ± 0.1 15.3 ± 0.1 15.2 ± 0.1  
Metabolized energy (kJ/day) 51.3 ± 4.2 57.5 ± 1.7 56.4 ± 3.5 54.9 ± 1.7  
Metabolized energy / body weight (kJ/g/day) 1.55 ± 0.12 1.45 ± 0.06 1.78 ± 0.09 1.53 ± 0.07  
Food assimilation coefficient (%) 77.0 ± 1.7 79.1 ± 1.1 80.7 ± 1.8 78.3 ± 0.4  
  1. 23-24 week-old mice (n = 7 per genotype and sex) were tested under ad libitum conditions. Data are presented as mean ± standard error of mean. Student’s t-test: homozygous mutants (males and females) vs. heterozygous mutants (males and females) as controls: a, P < 0.05; c, P < 0.001.