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Table 4 Analysis of energy metabolism of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

 

Males

Females

 

Parameter

Homozygous mutants

Heterozygous mutants

Homozygous mutants

Heterozygous mutants

t-test

Body weight (g)

33.0 ± 0.4

40.0 ± 1.1

31.7 ± 1.3

36.2 ± 1.3

c

Rectal body temperature (°C)

36.2 ± 0.04

36.3 ± 0.1

36.7 ± 0.1

36.6 ± 0.1

 

Food intake (g/day)

3.7 ± 0.2

4.1 ± 0.1

3.9 ± 0.2

3.9 ± 0.1

 

Energy uptake (kJ/day)

66.2 ± 4.2

72.6 ± 1.6

69.9 ± 4.0

70.1 ± 2.0

 

Energy uptake / body weight (kJ/g/day)

2.0 ± 0.1

1.8 ± 0.1

2.2 ± 0.1

2.0 ± 0.1

a

Feces production (g/day)

0.91 ± 0.04

0.91 ± 0.05

0.81 ± 0.08

0.93 ± 0.02

 

Energy content of feces (kJ/g)

15.3 ± 0.1

15.4 ± 0.1

15.3 ± 0.1

15.2 ± 0.1

 

Metabolized energy (kJ/day)

51.3 ± 4.2

57.5 ± 1.7

56.4 ± 3.5

54.9 ± 1.7

 

Metabolized energy / body weight (kJ/g/day)

1.55 ± 0.12

1.45 ± 0.06

1.78 ± 0.09

1.53 ± 0.07

 

Food assimilation coefficient (%)

77.0 ± 1.7

79.1 ± 1.1

80.7 ± 1.8

78.3 ± 0.4

 
  1. 23-24 week-old mice (n = 7 per genotype and sex) were tested under ad libitum conditions. Data are presented as mean ± standard error of mean. Student’s t-test: homozygous mutants (males and females) vs. heterozygous mutants (males and females) as controls: a, P < 0.05; c, P < 0.001.