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Table 5 Immunology analysis of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

  Males Females
Parameter Homozygous mutants Heterozygous mutants Homozygous mutants Heterozygous mutants
CD3+ 38.8 ± 1.8 35.1 ± 2.3 37.4 ± 1.7 36.1 ± 1.3
CD4+ 25.7 ± 1.2 22.9 ± 1.6 23.3 ± 1.3 21.9 ± 1.1
CD8β+ 22.2 ± 0.9 20.6 ± 1.6 22.9 ± 1.0 22.4 ± 1.0
CD19+ 28.9 ± 1.1 31.1 ± 1.1 30.3 ± 1.1 29.6 ± 1.0
CD19+CD5+ 3.5 ± 0.2 3.3 ± 0.2 3.9 ± 0.2 3.5 ± 0.1
CD19+CD5 96.4 ± 0.2 96.5 ± 0.2 95.9 ± 0.2 96.3 ± 0.1
CD49b+ 29.9 ± 1.5b 23.0 ± 1.6 28.8 ± 1.9 27.3 ± 1.6
Gr1+ 31.7 ± 0.8 37.0 ± 2.1 27.0 ± 1.4 30.0 ± 1.3
IgA 445 ± 14 453 ± 40 475 ± 18 478 ± 17
IgG1 130 ± 12 158 ± 17 174 ± 13 211 ± 20
IgG2a 385 ± 25 476 ± 34 558 ± 43 518 ± 35
IgG2b 94 ± 4a 147 ± 21 175 ± 10 165 ± 8
IgG3 324 ± 25a 424 ± 18 465 ± 25 408 ± 22
IgM 1338 ± 142 1782 ± 275 1623 ± 164 1590 ± 195
  1. Data are frequencies of main leukocyte subsets in blood (%) and concentration (μg/ml) of antibodies of different isotypes in plasma.
  2. 17-week-old mice were tested. No. per genotype and sex: n = 15. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01.