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Table 5 Immunology analysis of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

 

Males

Females

Parameter

Homozygous mutants

Heterozygous mutants

Homozygous mutants

Heterozygous mutants

CD3+

38.8 ± 1.8

35.1 ± 2.3

37.4 ± 1.7

36.1 ± 1.3

CD4+

25.7 ± 1.2

22.9 ± 1.6

23.3 ± 1.3

21.9 ± 1.1

CD8β+

22.2 ± 0.9

20.6 ± 1.6

22.9 ± 1.0

22.4 ± 1.0

CD19+

28.9 ± 1.1

31.1 ± 1.1

30.3 ± 1.1

29.6 ± 1.0

CD19+CD5+

3.5 ± 0.2

3.3 ± 0.2

3.9 ± 0.2

3.5 ± 0.1

CD19+CD5−

96.4 ± 0.2

96.5 ± 0.2

95.9 ± 0.2

96.3 ± 0.1

CD49b+

29.9 ± 1.5b

23.0 ± 1.6

28.8 ± 1.9

27.3 ± 1.6

Gr1+

31.7 ± 0.8

37.0 ± 2.1

27.0 ± 1.4

30.0 ± 1.3

IgA

445 ± 14

453 ± 40

475 ± 18

478 ± 17

IgG1

130 ± 12

158 ± 17

174 ± 13

211 ± 20

IgG2a

385 ± 25

476 ± 34

558 ± 43

518 ± 35

IgG2b

94 ± 4a

147 ± 21

175 ± 10

165 ± 8

IgG3

324 ± 25a

424 ± 18

465 ± 25

408 ± 22

IgM

1338 ± 142

1782 ± 275

1623 ± 164

1590 ± 195

  1. Data are frequencies of main leukocyte subsets in blood (%) and concentration (μg/ml) of antibodies of different isotypes in plasma.
  2. 17-week-old mice were tested. No. per genotype and sex: n = 15. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01.
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Journal of Biomedical Science

ISSN: 1423-0127