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Table 6 Analysis of lung function of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

  Males Females
Parameter Homozygous mutants Heterozygous mutants Homozygous mutants Heterozygous mutants
Body weight (g) 33.6 ± 0.8 a 38.9 ± 1.5 34.8 ± 1.4 36.3 ± 2.0
Mean f (1/min) 334 ± 19 354 ± 7 355 ± 23 308 ± 25
Sleep f (1/min) 125 ± 5 b 149 ± 4 130 ± 7 128 ± 6
Rest f (1/min) 277 ± 19 297 ± 4 293 ± 11a 251 ± 13
Activity f (1/min) 468 ± 6 474 ± 11 460 ± 5 426 ± 20
Sleep sTV (μl/g) 8.4 ± 0.2 7.3 ± 0.4 9.4 ± 0.5 8.5 ± 0.6
Rest sTV (μl/g) 6.0 ± 0.2 5.5 ± 0.3 6.5 ± 0.3 6.3 ± 0.3
Activity sTV (μl/g) 5.8 ± 0.2 5.5 ± 0.4 6.2 ± 0.2a 5.5 ± 0.2
Sleep sMV (ml/min/g) 1.0 ± 0.04 1.1 ± 0.1 1.2 ± 0.04 1.1 ± 0.1
Rest sMV (ml/min/g) 1.5 ± 0.1 1.5 ± 0.1 1.8 ± 0.1b 1.4 ± 0.04
Activity sMV (ml/min/g) 2.7 ± 0.1 2.5 ± 0.2 2.8 ± 0.1b 2.3 ± 0.1
  1. f, respiratory rates; mean f (1/min), the mean of all breathing frequencies (mean f) measured during the 40-minute examination period was calculated as a parameter to assess whether the duration of rest and activity was similar in all groups; sTV, specific tidal volumes and sMV, specific minute ventilations were calculated by relating the absolute values to the body weight of the animals.
  2. 21-week-old mice were tested. No. per genotype and sex: n = 5–6. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01.