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Table 6 Analysis of lung function of line Slc12a1 I299F

From: Standardized, systemic phenotypic analysis of Slc12a1I299F mutant mice

 

Males

Females

Parameter

Homozygous mutants

Heterozygous mutants

Homozygous mutants

Heterozygous mutants

Body weight (g)

33.6 ± 0.8 a

38.9 ± 1.5

34.8 ± 1.4

36.3 ± 2.0

Mean f (1/min)

334 ± 19

354 ± 7

355 ± 23

308 ± 25

Sleep f (1/min)

125 ± 5 b

149 ± 4

130 ± 7

128 ± 6

Rest f (1/min)

277 ± 19

297 ± 4

293 ± 11a

251 ± 13

Activity f (1/min)

468 ± 6

474 ± 11

460 ± 5

426 ± 20

Sleep sTV (μl/g)

8.4 ± 0.2

7.3 ± 0.4

9.4 ± 0.5

8.5 ± 0.6

Rest sTV (μl/g)

6.0 ± 0.2

5.5 ± 0.3

6.5 ± 0.3

6.3 ± 0.3

Activity sTV (μl/g)

5.8 ± 0.2

5.5 ± 0.4

6.2 ± 0.2a

5.5 ± 0.2

Sleep sMV (ml/min/g)

1.0 ± 0.04

1.1 ± 0.1

1.2 ± 0.04

1.1 ± 0.1

Rest sMV (ml/min/g)

1.5 ± 0.1

1.5 ± 0.1

1.8 ± 0.1b

1.4 ± 0.04

Activity sMV (ml/min/g)

2.7 ± 0.1

2.5 ± 0.2

2.8 ± 0.1b

2.3 ± 0.1

  1. f, respiratory rates; mean f (1/min), the mean of all breathing frequencies (mean f) measured during the 40-minute examination period was calculated as a parameter to assess whether the duration of rest and activity was similar in all groups; sTV, specific tidal volumes and sMV, specific minute ventilations were calculated by relating the absolute values to the body weight of the animals.
  2. 21-week-old mice were tested. No. per genotype and sex: n = 5–6. Data are presented as mean ± standard error of mean. Student’s t-test vs. heterozygous mutants as controls: aP < 0.05, bP < 0.01.
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Journal of Biomedical Science

ISSN: 1423-0127