Relationship between post-cardiac arrest myocardial oxidative stress and myocardial dysfunction in the rat

Table 2 Circulating oxidative stress biomarkers and asymmetrical dimethylarginine (ADMA) and dimethylarginine dimethylaminohydrolase (DDAH)

	Baseline	PR 2 h	PR 4 h	PR 72 h
	(n = 8)	(n = 9)	(n = 6)	(n = 8)
Plasma hs-cTnT, ng/L	61 [20-91]	3732 [3277-6218]**	3469 [2428-4930]*	44 [39-1610]
Plasma IsoP, pg/mL	235.6 ± 28.8	206.2 ± 14.9	306.6 ± 21.6*	216.6 ± 30.0
Plasma 8-OHG, pg/mL	742.9 ± 79.3	1044.5 ± 71.1*	914.9 ± 104.1	846.9 ± 14.7
Plasma GSH, μmol/mL	0.146 ± 0.030	0.099 ± 0.004	0.095 ± 0.013	0.136 ± 0.023
Plasma ADMA, μmol/L	0.767 ± 0.10	0.641 ± 0.07	0.468 ± 0.06*	0.601 ± 0.07
Myocardial ADMA, nmol/mg prot	0.083 ± 0.01	0.052 ± 0.01	0.043 ± 0.01	0.080 ± 0.02
Myocardial DDAH, nmol/mg prot	77.5 ± 12.7	73.5 ± 7.2	79.0 ± 10.4	90.0 ± 12.8

PR, post resuscitation; 8-OHG, 8-hydroxyguanosine; hs-cTnT, high-sensitivity cardiac troponin T; IsoP, isoprostanes; GSH, glutathione S-transferase.
Parametric data are shown as mean ± SEM; Non-parametric data are shown as median [25-75 percentile].
*p < 0.05 vs. Baseline; **p < 0.01 vs. Baseline.

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