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Table 2 Circulating oxidative stress biomarkers and asymmetrical dimethylarginine (ADMA) and dimethylarginine dimethylaminohydrolase (DDAH)

From: Relationship between post-cardiac arrest myocardial oxidative stress and myocardial dysfunction in the rat

  Baseline PR 2 h PR 4 h PR 72 h
(n = 8) (n = 9) (n = 6) (n = 8)
Plasma hs-cTnT, ng/L 61 [20-91] 3732 [3277-6218]** 3469 [2428-4930]* 44 [39-1610]
Plasma IsoP, pg/mL 235.6 ± 28.8 206.2 ± 14.9 306.6 ± 21.6* 216.6 ± 30.0
Plasma 8-OHG, pg/mL 742.9 ± 79.3 1044.5 ± 71.1* 914.9 ± 104.1 846.9 ± 14.7
Plasma GSH, μmol/mL 0.146 ± 0.030 0.099 ± 0.004 0.095 ± 0.013 0.136 ± 0.023
Plasma ADMA, μmol/L 0.767 ± 0.10 0.641 ± 0.07 0.468 ± 0.06* 0.601 ± 0.07
Myocardial ADMA, nmol/mg prot 0.083 ± 0.01 0.052 ± 0.01 0.043 ± 0.01 0.080 ± 0.02
Myocardial DDAH, nmol/mg prot 77.5 ± 12.7 73.5 ± 7.2 79.0 ± 10.4 90.0 ± 12.8
  1. PR, post resuscitation; 8-OHG, 8-hydroxyguanosine; hs-cTnT, high-sensitivity cardiac troponin T; IsoP, isoprostanes; GSH, glutathione S-transferase.
  2. Parametric data are shown as mean ± SEM; Non-parametric data are shown as median [25-75 percentile].
  3. *p < 0.05 vs. Baseline; **p < 0.01 vs. Baseline.