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Figure 1 | Journal of Biomedical Science

Figure 1

From: NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes

Figure 1

The activation of IP-10 and IL-8 in THP-1 cells treated with H. TB. (A) MTT cytotoxicity assay shows the cell viability of THP-1 cells when treated with H. TB at variable concentrations (2.5, 5, 10, 20 μg/ml) for 6 hours. The cell viability decreased when THP-1 cells treated with H. TB at the concentration of 20 μg/ml (n = 5) compared with control. (B) The expression of IP-10 (Left panel) and IL-8 (Right panel) mRNA in THP-1 (n = 5) cells was concentration-dependently increased when treated with H. TB for 2 hours, reaching the maximum at 10 μg/ml. (C) The release of IP-10 and IL-8 proteins by THP-1 cells (n = 5) was concentration-dependently increased when treated with H. TB for 6 hours, reaching the maximum at 10 μg/ml. Data are means ± SE. *p < 0.05, **p < 0.01 compare with the vehicle control.

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