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Figure 4 | Journal of Biomedical Science

Figure 4

From: NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes

Figure 4

p65 and NKRF binding to IP-10 and IL-8 promoter sites by ChIP assays. (A) The ChIP assays showed a higher binding of p65 to IP-10 (left panel) and IL-8 (right panel) promoter sites in THP-1 cells treated with H. TB (5 μg/ml). (B) The ChIP assays showed a higher binding of NKRF to IP-10 (left panel) and IL-8 (right panel) promoter sites in THP-1 cells treated with H. TB (5 μg/ml) (C) H. TB (5 μg/ml) induced NKRF binding to IP-10 (left panel) and IL-8 (right panel) promoter sites in THP-1 cells is time-dependent. Data are means ± SE. *p < 0.05, **p < 0.01 compared with control.

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