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Figure 5 | Journal of Biomedical Science

Figure 5

From: NF-κB repressing factor downregulates basal expression and mycobacterium tuberculosis induced IP-10 and IL-8 synthesis via interference with NF-κB in monocytes

Figure 5

Inhibition of NKRF increased the release of IP-10 and IL-8. (A) THP-1 cells transfected with siRNA targeting NKRF (NKRF-RNAi) for 48 hours significantly enhanced the release of IP-10 (left panel) and IL-8 (right panel) proteins with or without H. TB (5 μg/ml) stimulation, when compared with corresponding scramble control (Scramble). (B) THP-1 cells transfected with NKRF plasmid (p-CMV-NKRF) for 24 hours significantly decreased the protein levels of IP-10 (left panel) and IL-8 (right panel) in THP-1 cells with or without H. TB (5 μg/ml) stimulation, when compared with corresponding vector control (p-CMV-vector). Data are means ± SE. *p < 0.05 compared with the corresponding group without H. TB treatment; #p < 0.05 compared with the corresponding Scramble or vector control group.

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