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Figure 2 | Journal of Biomedical Science

Figure 2

From: Folic acid supplementation in pregnancy and implications in health and disease

Figure 2

A representative integrative model of possible epigenetic influence on pregnancy outcomes. Maternal intake of FA may result in epigenetic modulation in the offspring brain methylome with overall or site specific alterations of methylation in genomic DNA, non-coding RNA and histone modifications. These effects may alter gene expression of several imprinted, candidate autism susceptibility and key developmental genes. Such changes may impact other biological processes, and associate with the overall developmental outcome. Scientific artwork adapted from [137],[138].

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