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Figure 6 | Journal of Biomedical Science

Figure 6

From: Fibroblast Growth Factor-2 alone as an efficient inducer for differentiation of human bone marrow mesenchymal stem cells into dopaminergic neurons

Figure 6

Dopamine release and Ca2+ imaging analysis of MSC derived DA neurons induced with FGF2, Shh/FGF8, ATRA, and Shh/FGF8/ATRA A) Western Blot showing expression of TH in hBM MSC induced with different media cocktails and a baseline in UI group. B) Graph showing the level of dopamine released in the media by hBM MSC upon induction with different inducers under study. Maximum concentration of dopamine was released by cells induced with FGF2 only as neuronal inducer. C) Graphs represent treatment with FGF2 induces elevated Ca2+ transient upon depolarization with KCl along with other culture media. The uninduced MSC doesn't show any net change in the intracellular Ca2+ concentration after depolarization. The block arrows indicate the addition of KCl for depolarization.

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Journal of Biomedical Science

ISSN: 1423-0127