Daysα
|
Group I (n = 6)
|
Group II
|
Group III
|
Group IV
|
Group V
|
---|
Bodyweight (g)
| | | | | |
0
|
140.40 ± 1.24
|
130.70 ± 3.18
|
131.01 ± 3.42
|
133.57 ± 2.66
|
133.38 ± 2.27
|
7
|
173.49 ± 2.34
|
134.37 ± 2.01a*
|
145.59 ± 2.82a*
|
142.27 ± 3.70a*
|
140.42 ± 2.10a*
|
14
|
218.31 ± 3.32
|
151.16 ± 2.64
|
160.88 ± 2.69
|
164.90 ± 3.38
|
150.82 ± 3.01
|
21
|
240.39 ± 2.75
|
171.17 ± 3.04
|
180.17 ± 3.25
|
190.76 ± 3.39
|
171.42 ± 3.35
|
28
|
261.11 ± 2.87
|
195.13 ± 3.70a*
|
191.80 ± 2.06a*
|
220.14 ± 2.68a* b*c*
|
201.73 ± 2.51a* b*c*
|
Urine pH
| | | | | |
0
|
7.07 ± 0.11
|
6.83 ± 0.26
|
6.84 ± 0.19
|
6.74 ± 0.25
|
6.54 ± 0.15
|
7
|
7.13 ± 0.16
|
7.08 ± 0.18
|
6.94 ± 0.20
|
7.11 ± 0.18
|
7.29 ± 0.12
|
14
|
7.10 ± 0.22
|
6.94 ± 0.30
|
6.94 ± 0.24
|
6.97 ± 0.20
|
7.02 ± 0.15
|
21
|
7.21 ± 0.15
|
6.44 ± 0.19a*
|
6.55 ± 0.12a*
|
6.86 ± 0.21b*c*
|
6.94 ± 0.16
|
28
|
7.25 ± 0.11
|
6.09 ± 0.07a*
|
6.16 ± 0.08a*
|
6.90 ± 0.17a* b*c*
|
6.79 ± 0.13a* b*c*
|
Uric acid (mg/24 h)
| | | | | |
0
|
0.05 ± 0.01
|
0.09 ± 0.01
|
0.06 ± 0.01
|
0.05 ± 0.01
|
0.05 ± 0.01
|
7
|
0.12 ± 0.01
|
0.14 ± 0.01
|
0.16 ± 0.01
|
0.07 ± 0.01
|
0.12 ± 0.04
|
14
|
0.11 ± 0.02
|
0.18 ± 0.01a*
|
0.19 ± 0.01a*
|
0.09 ± 0.01b*c*
|
0.14 ± 0.01b*c*
|
21
|
0.15 ± 0.02
|
0.21 ± 0.02a*
|
0.25 ± 0.03a*
|
0.11 ± 0.03b*c*
|
0.15 ± 0.01b*c*
|
28
|
0.17 ± 0.02
|
0.46 ± 0.02a*
|
0.39 ± 0.03a*
|
0.12 ± 0.01b*c*
|
0.18 ± 0.02b*c*
|
Creatinine (mg/24 h)
| | | | | |
0
|
1.33 ± 0.08
|
1.39 ± 0.18
|
1.23 ± 0.15
|
1.11 ± 0.11
|
1.16 ± 0.08
|
7
|
1.04 ± 0.06
|
1.50 ± 0.16a*
|
1.69 ± 0.26a*
|
1.41 ± 0.11a*
|
1.73 ± 0.10a*
|
14
|
1.64 ± 0.24
|
1.73 ± 0.13a*
|
2.82 ± 0.29a*
|
1.61 ± 0.18c*
|
1.95 ± 0.18c*
|
21
|
1.51 ± 0.31
|
2.71 ± 0.19a*
|
3.19 ± 0.22a*
|
2.07 ± 0.09a*b*c*
|
2.30 ± 0.16a*b*c*
|
28
|
1.77 ± 0.23
|
3.69 ± 0.30a*
|
3.52 ± 0.19a*
|
2.52 ± 0.14a*b*c*
|
3.07 ± 0.61a*c*
|
- α Data are expressed as mean ± SD. Comparisons are made against Group I (Control)a , Group II (lithiatic control)b and Group III (Non-recombinant strain)c.
- a*b* and c* indicates the mean value is significant at p < 0.05 against group I, II and III correspondingly. n = 6 rats each group.