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Table 2 Sequences of wild-type and mutant CPT1A promoter constructs in mutational analysis

From: Flavonoid ingredients of Ginkgo biloba leaf extract regulate lipid metabolism through Sp1-mediated carnitine palmitoyltranferase 1A up-regulation

Name

Sequence (46 bp)a

 

–50

Sp1a

Sp1b

Wild type

gtccctGCCCCGCCCGgcctgcaggtggcaccTAGGCGGCGCgcag

Sp1a mut.

gtccctGCCTAA CCCT gcctgcaggtggcaccTAGGCGGCGCgcag

Sp1b mut.

gtccctGCCCCGCCCGgcctgcaggtggcaccTAGGTAA CGCgcag

Sp1a-b mut.

gtccctGCCTAA CCCT gcctgcaggtggcaccTAGGTAA CGCgcag

  1. aPutative cis-elements were indicated with capital, and introduced mutations were shown in bold.
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Journal of Biomedical Science

ISSN: 1423-0127