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Figure 4 | Journal of Biomedical Science

Figure 4

From: X-Linked thrombocytopenia causing mutations in WASP (L46P and A47D) impair T cell chemotaxis

Figure 4

JurkatWASP-KDT cells expressing WASP mutants exhibit abnormal actin cytoskeleton reorganization upon SDF-1α stimulation. A) WT or JurkatWASP-KD T cells expressing WASPR or mutants were plated on poly-L-lysine coated coverslip, stimulated for 5 min with SDF-1α, fixed and stained with Alexa 594 phalloidin. Arrows indicate the actin patches. B) Quantification of actin polarization from three independent experiments as described in materials and methods. **p < 0.01 compared to WT Jurkat T cells.

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