Figure 3

Diabetes aggravated FC I/R-induced brain infarction and neurological deficits were rescued by insulin treatment. The diabetic rats were induced by intravenous injection of STZ (65 mg/kg) and then were used 2 weeks later. Insulin (4 IU rat^-1 day^-1) was subcutaneously injected in STZ-diabetic rats for 1 week. Infarct volumes were determined after 1-h focal cerebral ischemia followed by 24-h reperfusion. Representative coronal sections (A). Mean ± SEM of quantitative infarct volume (B). The neurological functions were examined by Bederson score (C) in age-matched non-diabetic control (n = 10), DM (n = 10), and insulin-treated diabetic rats (DMI, n = 10). Values are expressed as mean ± SEM.