Skip to main content

Table 1 Altered expression of miRNA-5p and -3p pairs in colon cancer cells relative to normal cells 1

From: MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells

Family miRNA-5p Log2(fold change) miRNA-3p Log2(fold change)
(Mean ± SD) (Mean ± SD)
1. 5p/3p co-upregulated (n = 14)
let-7 let-7g-5p 2.97 ± 0.49** let-7g-3p 2.12 ± 0.13*
let-7 let-7i-5p 2.81 ± 1.27* let-7i-3p 1.67±0.45*
mir-7 miR-7-5p 6.44 ± 1.14* miR-7-1-3p 3.83±0.66**
mir-8/200 miR-141-5p 3.85 ± 0.76** miR-141-3p 4.50 ± 1.08**
mir-8/200 miR-200a-5p 5.17 ± 0.65** miR-200a-3p 8.10 ± 1.58**
mir-17 miR-17-5p 6.68 ± 0.69** miR-17-3p 4.12 ± 0.59**
mir-17 miR-18a-5p 3.94 ± 0.91** miR-18a-3p 3.18 ± 0.77**
mir-17 miR-20a-5p 7.19 ± 0.78** miR-20a-3p 1.58 ± 0.98
mir-21 miR-21-5p 9.13 ± 0.39** miR-21-3p 5.99 ± 0.85**
mir-22 miR-22-5p 1.98 ± 0.78 miR-22-3p 3.22 ± 0.76**
mir-27 miR-27a-5p 2.94 ± 1.21** miR-27a-3p 4.78 ± 0.62**
mir-28 miR-151a-5p 2.65 ± 0.67* miR-151a-3p 5.39 ± 1.20 **
mir-29 miR-29b-1-5p 0.93 ± 0.84 miR-29b-1-3p 7.62 ± 0.32**
mir-31 miR-31-5p 8.88 ± 1.73** miR-31-3p 2.08 ± 0.76**
2. 5p/3p co-downregulated (n = 3)
mir-199 miR-199a-5p −3.84 ± 2.16** miR-199a-3p −3.23 ± 1.55**
mir-378 miR-378a-5p −2.60 ± 0.008** miR-378a-3p −1.04 ± 0.27
mir-574 miR-574-5p −2.90 ± 0.44* miR-574-3p −3.94 ± 0.21**
3. 5p/3p inversed regulation (n = 2)
let-7 let-7d-5p 2.29 ± 1.01 let-7d-3p −2.78 ± 0.79**
mir-8/200 miR-200b-5p −1.67 ± 0.39 miR-200b-3p 3.15 ± 0.25**
  1. 1Based on miRBase 19 data; a full list of alternative miRNA names is provided in Additional file 1. *p < 0.0 5, **p < 0.01.