MicroRNA-5p and -3p co-expression and cross-targeting in colon cancer cells

Table 1 Altered expression of miRNA-5p and -3p pairs in colon cancer cells relative to normal cells ¹

Family	miRNA-5p	Log₂(fold change)	miRNA-3p	Log₂(fold change)
Family	miRNA-5p	(Mean ± SD)	miRNA-3p	(Mean ± SD)
1. 5p/3p co-upregulated (n = 14)
let-7	let-7g-5p	2.97 ± 0.49**	let-7g-3p	2.12 ± 0.13*
let-7	let-7i-5p	2.81 ± 1.27*	let-7i-3p	1.67±0.45*
mir-7	miR-7-5p	6.44 ± 1.14*	miR-7-1-3p	3.83±0.66**
mir-8/200	miR-141-5p	3.85 ± 0.76**	miR-141-3p	4.50 ± 1.08**
mir-8/200	miR-200a-5p	5.17 ± 0.65**	miR-200a-3p	8.10 ± 1.58**
mir-17	miR-17-5p	6.68 ± 0.69**	miR-17-3p	4.12 ± 0.59**
mir-17	miR-18a-5p	3.94 ± 0.91**	miR-18a-3p	3.18 ± 0.77**
mir-17	miR-20a-5p	7.19 ± 0.78**	miR-20a-3p	1.58 ± 0.98
mir-21	miR-21-5p	9.13 ± 0.39**	miR-21-3p	5.99 ± 0.85**
mir-22	miR-22-5p	1.98 ± 0.78	miR-22-3p	3.22 ± 0.76**
mir-27	miR-27a-5p	2.94 ± 1.21**	miR-27a-3p	4.78 ± 0.62**
mir-28	miR-151a-5p	2.65 ± 0.67*	miR-151a-3p	5.39 ± 1.20 **
mir-29	miR-29b-1-5p	0.93 ± 0.84	miR-29b-1-3p	7.62 ± 0.32**
mir-31	miR-31-5p	8.88 ± 1.73**	miR-31-3p	2.08 ± 0.76**
2. 5p/3p co-downregulated (n = 3)
mir-199	miR-199a-5p	−3.84 ± 2.16**	miR-199a-3p	−3.23 ± 1.55**
mir-378	miR-378a-5p	−2.60 ± 0.008**	miR-378a-3p	−1.04 ± 0.27
mir-574	miR-574-5p	−2.90 ± 0.44*	miR-574-3p	−3.94 ± 0.21**
3. 5p/3p inversed regulation (n = 2)
let-7	let-7d-5p	2.29 ± 1.01	let-7d-3p	−2.78 ± 0.79**
mir-8/200	miR-200b-5p	−1.67 ± 0.39	miR-200b-3p	3.15 ± 0.25**

¹Based on miRBase 19 data; a full list of alternative miRNA names is provided in Additional file 1. *p < 0.0 5, **p < 0.01.

ISSN: 1423-0127