Two types of ground glass hepatocytes and the corresponding deletions at pre-S regions of large surface protein. Ground glass hepatocytes (GGH) and the expression patterns of hepatitis B surface antigens. Type I GGH are usually scattered singly and express an inclusion-like pattern of the surface antigen, while type II GGH consistently cluster in nodules and express a marginal pattern of the surface antigen (A). The profile of deletions over the pre-S regions in sera of HBV-related HCC patients. A complex combination of deletions at pre-S1 and pre-S2 regions may occur in patients of chronic HBV carriers (B). Hematoxylin-Eosin stain, HE; Immunohistochemical stain, IHC.