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Figure 7 | Journal of Biomedical Science

Figure 7

From: KUD773, a phenylthiazole derivative, displays anticancer activity in human hormone-refractory prostate cancers through inhibition of tubulin polymerization and anti-Aurora A activity

Figure 7

Effect of KUD773 on MMP expression and histone H3 acetylation and phosphorylation. PC-3 cells were incubated in the absence or presence of KUD773 (3 μM) for various times (A) or the indicated agent for 24 h (B). Cells were harvested and lysed for the detection of the indicated protein expression by Western blot. The expression was quantified using the computerized image analysis system ImageQuant (Amersham Biosciences). The data are expressed as mean ± SEM of three independent experiments. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the control of 100%.

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