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Figure 1 | Journal of Biomedical Science

Figure 1

From: EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex

Figure 1

Schematic showing the cell specific silencing strategy mediated by PEI nanocomplex fabricated with aptamer and siRNA. PEI nanoparticle is formed using sodium citrate as charge stabilizer, followed by the addition of siRNA and EpCAM aptamer to form the PEI-Apt-siRNA complex. This complex guided by the aptamer, binds to the EpCAM positive cells and delivers the siRNA in the cytoplasm resulting in target gene silencing and inhibition of cellular function pertained to it.

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