Figure 8

Hypoxia increases proliferation activity of HCASMCs. Incorporation of [³H]Thymidine into HCASMCs increased under 2.5% hypoxia and exogenous addition of leptin, AngII, or Dp44mT (under normoxia) for 2 to 4 h. Hypoxia-induced incorporation of [³H]Thymidine into HCASMCs was suppressed by leptin siRNA, losartan, NAC, and SP600125. *P < 0.01 vs.normoxia control. ^#P < 0.01 vs. hypoxia (n = 6).