Regulation of cancer metastasis by microRNAs

Table 1 miRNAs known to regulate EMT-related molecules

miRNAs	Role of EMT regulation	Target (s)	Cancer types
miR-9	Positive	E-cadherin	Breast cancer [73], colorectal cancer [74]
miR-29a	Positive	TTP	Breast cancer [75]
miR-21	Positive	PTEN, RECK	Breast cancer [76], gastric cancer [77]
miR-103/107	Positive	Dicer	Breast cancer [78]
miR-221/222	Positive	Dicer, ESR1, TRPS1	Breast cancer [79]
miR-30a	Negative	Snail, Vimentin	Lung cancer [61], liver cancer [62], gastric cancer [63]
miR-34a	Negative	Snail, ZNF281, IL-6R	Colorectal cancer [65]
miR-200 family	Negative	ZEB1/2, ERRFI-1	Bladder cancer [58], breast cancer [56,57], ovarian cancer [55,57], lung cancer [57]
miR-204	Negative	Slug	Cholangiocarcinoma [64]
miR-205	Negative	ZEB1/2	Breast cancer [56]

ISSN: 1423-0127