Table 2 miRNAs involved in metastasis-related cell behaviors
Role of metastasis regulation | Metastasis-relevant phenotypes | Target (s) | Cancer types | |
|---|---|---|---|---|
miR-10b | Positive | migration, invasion, colonization | HOXD10, KLF4 | |
miR-373/503c | Positive | migration, invasion | CD44 | Breast cancer [86] |
miR-31 | Negative | migration, invasion | RhoA, radixin, α5 integrin | Breast cancer [87] |
miR-126 | Negative | migration, invasion, adhesion, angiogenesis | VEGFA, CRK | |
miR-149 | Negative | migration, invasion, adhesion | GIT1 | Breast cancer [91] |
miR-491-5p | Negative | migration, invasion, adhesion | GIT1 | Oral cancer [92] |
miR-138 | Negative | migration, invasion | HIF1A, SOX4, RhoC | |
miR-127 | Negative | migration | BCL6 | Breast cancer [96] |
miR-206 | Negative | migration | Notch3, CDK4, Cyclin D | |
miR-335 | Negative | migration, invasion, colonization | SOX4, TNC | Breast cancer [99] |