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Table 1 The differences of the single nucleotide polymorphisms in the ITGA5 , ITGB1 , IL10 , COX-2 , RUNX3 , and TFF2 genes between 195 children of gastric cancer patients and 143 duodenal ulcer patients

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Parameters N (%)

GCA children

DU patients

P *

P **

OR (95% CI)

Age (yr)

38.2 ± 10.6

49.2 ± 13.8

1×10-4

  

Gender (F: M)

99 (51): 96 (49)

59 (41): 84 (59)

0.050

0.096

1.5 (1.0 - 2.3)

H. pylori (+: -)

88 (48): 97 (52)

110 (79): 29 (21)

<1×10-4

<1×10-4

0.2 (0.1 - 0.4)

ITGA5

     

  ITGA5 -1160

(N = 195)

(N = 139)

   

  T-carrier: GG

154 (79): 41 (21)

90 (65): 49 (35)

0.017

0.006

2.2 (1.2 - 4.0)

  ITGA5 -240

(N = 193)

(N = 138)

   

  CC: CT

190 (98): 3 (2)

136 (99): 2 (1)

0.751

1.000

0.3 (0.0 - 3.1)

ITGB1

     

  ITGB1 -1949

(N = 189)

(N = 136)

   

  A-carrier: GG

158 (84): 31 (16)

101 (74): 35 (26)

0.047

0.047

2.8 (1.4 - 5.3)

  ITGB1 -1840

(N = 189)

(N = 136)

   

  CC: T-carrier

100 (53): 89 (47)

75 (55): 61 (45)

0.872

0.735

0.9 (0.6 - 1.6)

  ITGB1 -1575

(N = 189)

(N = 136)

   

  AA: G-carrier

10 (5): 179 (95)

15 (11): 121 (89)

0.034

0.059

0.3 (0.1 - 0.8)

  ITGB1 -685

(N = 185)

(N = 126)

   

  -/-: -/C

26 (14): 159 (86)

13 (10): 113 (90)

0.633

0.386

1.5 (0.7 - 3.4)

  IGB1 -1660

(N = 192)

(N = 138)

   

  TTTAA/TTTAA: others

165 (86): 27 (14)

117 (85): 21 (15)

0.385

0.877

0.9 (0.5 - 1.7)

  ITGB1 +31804

(N = 189)

(N = 136)

   

  C-carrier: TT

180 (95): 9 (5)

119 (88): 17 (13)

0.003

0.013

4.7 (1.7 - 13.0)

  ITGB1 +32492

(N = 189)

(N = 136)

   

  G-carrier: AA

97 (51): 92 (49)

57 (42): 79 (58)

0.022

0.113

1.7 (1.0 - 2.9)

IL10

     

  IL10 -1082

(N = 190)

(N = 138)

   

  AA: G-carrier

172 (91): 18 (9)

121 (88): 17 (12)

0.216

0.839

1.7 (0.7 - 3.9)

  IL10 -819

(N = 193)

(N = 138)

   

  TT: C-carrier

101 (52): 92 (48)

53 (38): 85 (62)

0.022

0.014

2.3 (1.4 - 4.0)

  IL10 -592

(N = 193)

(N = 138)

   

  AA: C-carrier

101 (52): 92 (48)

53 (38): 85 (62)

0.022

0.014

2.3 (1.4 - 4.0)

COX-2

     

  COX-2 -1195

(N = 189)

(N = 129)

   

  G-carrier: AA

156 (83): 33 (17)

92 (71): 37 (29)

0.064

0.019

1.7 (0.9 - 3.2)

  COX-2 +8473

(N = 194)

(N = 138)

   

  TT: C-carrier

134 (69): 60 (31)

84 (61): 54 (39)

0.259

0.129

1.4 (0.9 - 2.3)

RUNX3

     

  RUNX3 -18508

(N = 186)

(N = 135)

   

  C-carrier: GG

130 (70): 56 (30)

100 (74): 35 (26)

0.586

0.449

0.7 (0.4 - 1.2)

  RUNX3 -1714

(N = 193)

(N = 137)

   

  CC: A-carrier

109 (56): 84 (44)

68 (50): 69 (50)

0.302

0.261

1.3 (0.7 - 2.1)

  RUNX3 -1582

(N = 189)

(N = 136)

   

  T-carrier: CC

84 (44): 105 (56)

69 (51): 67 (49)

0.338

0.307

0.9 (0.5 - 1.4)

  RUNX3 -1166

(N = 193)

(N = 137)

   

  TT: C-carrier

109 (56): 84 (44)

68 (50): 69 (50)

0.302

0.258

1.3 (0.7 - 2.1)

  RUNX3 +492

(N = 189)

(N = 136)

   

  TT: A-carrier

106 (56): 83 (44)

67 (49): 69 (51)

0.312

0.263

1.2 (0.7 - 2.1)

  RUNX3 +73375

(N = 189)

(N = 135)

   

  CC: A-carrier

45 (24): 144 (76)

23 (17): 112 (83)

0.122

0.167

1.5 (0.8 - 2.9)

TFF2

     

  TFF2 -1373

(N = 189)

(N = 136)

   

  CC: T-carrier

139 (74): 50 (26)

97 (71): 39 (29)

0.692

0.702

1.0 (0.6 - 1.8)

  TFF2 -503

(N = 189)

(N = 136)

   

  AA: G-carrier

139 (74): 50 (26)

97 (71): 39 (29)

0.692

0.706

1.0 (0.6 - 1.8)

  TFF2 -308

(N = 189)

(N = 136)

   

  CC: A-carrier

85 (45): 104 (55)

53 (39): 83 (61)

0.394

0.311

1.2 (0.7 - 2.1)

  TFF2 +4649

(N = 188)

(N = 136)

   

  GG: A-carrier

100 (53): 88 (47)

64 (47): 72 (53)

0.343

0.308

1.4 (0.8 - 2.4)

  1. GCA: gastric cancer. DU: duodenal ulcer. SNPs: single nucleotide polymorphisms. *P value by mixed effect model. **P value by permutation test.