Skip to main content

Table 1 The differences of the single nucleotide polymorphisms in the ITGA5 , ITGB1 , IL10 , COX-2 , RUNX3 , and TFF2 genes between 195 children of gastric cancer patients and 143 duodenal ulcer patients

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Parameters N (%) GCA children DU patients P * P ** OR (95% CI)
Age (yr) 38.2 ± 10.6 49.2 ± 13.8 1×10-4   
Gender (F: M) 99 (51): 96 (49) 59 (41): 84 (59) 0.050 0.096 1.5 (1.0 - 2.3)
H. pylori (+: -) 88 (48): 97 (52) 110 (79): 29 (21) <1×10-4 <1×10-4 0.2 (0.1 - 0.4)
ITGA5      
ITGA5 -1160 (N = 195) (N = 139)    
  T-carrier: GG 154 (79): 41 (21) 90 (65): 49 (35) 0.017 0.006 2.2 (1.2 - 4.0)
ITGA5 -240 (N = 193) (N = 138)    
  CC: CT 190 (98): 3 (2) 136 (99): 2 (1) 0.751 1.000 0.3 (0.0 - 3.1)
ITGB1      
ITGB1 -1949 (N = 189) (N = 136)    
  A-carrier: GG 158 (84): 31 (16) 101 (74): 35 (26) 0.047 0.047 2.8 (1.4 - 5.3)
ITGB1 -1840 (N = 189) (N = 136)    
  CC: T-carrier 100 (53): 89 (47) 75 (55): 61 (45) 0.872 0.735 0.9 (0.6 - 1.6)
ITGB1 -1575 (N = 189) (N = 136)    
  AA: G-carrier 10 (5): 179 (95) 15 (11): 121 (89) 0.034 0.059 0.3 (0.1 - 0.8)
ITGB1 -685 (N = 185) (N = 126)    
  -/-: -/C 26 (14): 159 (86) 13 (10): 113 (90) 0.633 0.386 1.5 (0.7 - 3.4)
IGB1 -1660 (N = 192) (N = 138)    
  TTTAA/TTTAA: others 165 (86): 27 (14) 117 (85): 21 (15) 0.385 0.877 0.9 (0.5 - 1.7)
ITGB1 +31804 (N = 189) (N = 136)    
  C-carrier: TT 180 (95): 9 (5) 119 (88): 17 (13) 0.003 0.013 4.7 (1.7 - 13.0)
ITGB1 +32492 (N = 189) (N = 136)    
  G-carrier: AA 97 (51): 92 (49) 57 (42): 79 (58) 0.022 0.113 1.7 (1.0 - 2.9)
IL10      
IL10 -1082 (N = 190) (N = 138)    
  AA: G-carrier 172 (91): 18 (9) 121 (88): 17 (12) 0.216 0.839 1.7 (0.7 - 3.9)
IL10 -819 (N = 193) (N = 138)    
  TT: C-carrier 101 (52): 92 (48) 53 (38): 85 (62) 0.022 0.014 2.3 (1.4 - 4.0)
IL10 -592 (N = 193) (N = 138)    
  AA: C-carrier 101 (52): 92 (48) 53 (38): 85 (62) 0.022 0.014 2.3 (1.4 - 4.0)
COX-2      
COX-2 -1195 (N = 189) (N = 129)    
  G-carrier: AA 156 (83): 33 (17) 92 (71): 37 (29) 0.064 0.019 1.7 (0.9 - 3.2)
COX-2 +8473 (N = 194) (N = 138)    
  TT: C-carrier 134 (69): 60 (31) 84 (61): 54 (39) 0.259 0.129 1.4 (0.9 - 2.3)
RUNX3      
RUNX3 -18508 (N = 186) (N = 135)    
  C-carrier: GG 130 (70): 56 (30) 100 (74): 35 (26) 0.586 0.449 0.7 (0.4 - 1.2)
RUNX3 -1714 (N = 193) (N = 137)    
  CC: A-carrier 109 (56): 84 (44) 68 (50): 69 (50) 0.302 0.261 1.3 (0.7 - 2.1)
RUNX3 -1582 (N = 189) (N = 136)    
  T-carrier: CC 84 (44): 105 (56) 69 (51): 67 (49) 0.338 0.307 0.9 (0.5 - 1.4)
RUNX3 -1166 (N = 193) (N = 137)    
  TT: C-carrier 109 (56): 84 (44) 68 (50): 69 (50) 0.302 0.258 1.3 (0.7 - 2.1)
RUNX3 +492 (N = 189) (N = 136)    
  TT: A-carrier 106 (56): 83 (44) 67 (49): 69 (51) 0.312 0.263 1.2 (0.7 - 2.1)
RUNX3 +73375 (N = 189) (N = 135)    
  CC: A-carrier 45 (24): 144 (76) 23 (17): 112 (83) 0.122 0.167 1.5 (0.8 - 2.9)
TFF2      
TFF2 -1373 (N = 189) (N = 136)    
  CC: T-carrier 139 (74): 50 (26) 97 (71): 39 (29) 0.692 0.702 1.0 (0.6 - 1.8)
TFF2 -503 (N = 189) (N = 136)    
  AA: G-carrier 139 (74): 50 (26) 97 (71): 39 (29) 0.692 0.706 1.0 (0.6 - 1.8)
TFF2 -308 (N = 189) (N = 136)    
  CC: A-carrier 85 (45): 104 (55) 53 (39): 83 (61) 0.394 0.311 1.2 (0.7 - 2.1)
TFF2 +4649 (N = 188) (N = 136)    
  GG: A-carrier 100 (53): 88 (47) 64 (47): 72 (53) 0.343 0.308 1.4 (0.8 - 2.4)
  1. GCA: gastric cancer. DU: duodenal ulcer. SNPs: single nucleotide polymorphisms. *P value by mixed effect model. **P value by permutation test.