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Table 2 The comparisons of the genomic difference in the combinations of ITGA5 -1160 T-carrier, ITGB1 -1949 A-carrier, ITGB1 +31804 C-carrier, IL10 -592 AA and COX-2 -1195 G-carrier between the children of gastric cancer patients and the duodenal ulcer controls

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Predisposing SNPs Risk SNPs N (%) GCA children DU controls P * P ** OR (95% CI)
ITGA5 -1160   (N = 189) (N = 134)    
 T-carrier 3R:2R:1R:0R 126(67): 49(26): 12(6): 2(1) 63(47): 48(36): 18(13): 5(4) 0.002   
ITGB1 -1949       
 A-carrier 3R 126 (67) 63 (47) 0.225 0.050 5 (0.9 - 26.5)
ITGB1 +31804 2R 49 (26) 48 (36) 0.539 0.514 2.6 (0.5 - 13.8)
 C-carrier 1R 12 (6) 18 (23) 0.575 0.756 1.7 (0.3 - 10.0)
  0R 2 (21) 5 (4)    1
COX-2 -1195   (N = 188) (N = 125)    
 G-carrier 2R: 1R: 0R 80 (43): 93 (49): 15 (8) 31 (25): 75 (60): 19 (15) 0.013   
With or without       
IL-10 -592 AA 2R 80 (43) 31 (25) 0.021 0.005 3.3 (1.5 - 7.2)
1R 93 (49) 75 (60) 0.457 0.344 1.6 (0.7 - 3.3)
0R 15 (8) 19 (15)    1
ITGA5-1160   (N = 185) (N = 124)    
 T-carrier 2R: 1R: 0R 44 (24): 115 (62): 26 (14) 10 (8): 67 (54): 47 (38) <1×10-4   
ITGB1 -1949       
 A-carrier       
ITGB1 +31804 2R 44 (24) 10 (8) <1×10-4 <1×10-4 8.0 (3.4 - 18.4)
 C-carrier 1R 115 (62) 67 (54) 2×10-4 3×10-4 3.1 (1.8 - 5.5)
With or without 0R 26 (14) 47 (38)    1
COX-2 -1195       
 G-carrier
IL10 -592 AA
   (N = 193) (N = 135)    
IL-10 -592 AA 2R: 1R: 0R 74 (38): 105 (54): 14 (7) 33 (24): 73 (54): 29 (21) 4×10-4   
With or without       
ITGA5 -1160 2R 74 (38) 33 (24) 1×10-4 <1×10-4 4.6 (2.2 - 9.9)
 T-carrier 1R 105 (54) 73 (54) 6×10-4 0.003 3.0 (1.5 - 6.0)
0R 14 (7) 29 (21)    1
  1. GCA: gastric cancer. DU: duodenal ulcer. SNPs: single nucleotide polymorphisms. 3R: the presence of 3 predisposing SNPs with risk alleles. 2R: the presence of 2 predisposing SNPs with risky alleles.
  2. 1R: the presence of 1 predisposing SNP with risk allele. 0R: no any predisposing SNPs with risk alleles. *P value by mixed effect model; **P value by permutation test.