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Table 3 The difference of the H. pylori-related histological features between the children of gastric cancer patients with and without the risk allele genotypes as ITGA5-1160 T-carrier/ITGB1-1949 A-carrier/ITGB1+31804 C-carrier & COX-2-1195 G-carrier/IL10-592 AA

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Risks N (%) Pathology

ITGA5 -1160/ ITGB1 -1949/ ITGB1 +31804/ COX-2 -1195/ IL10 -592 as T*/A*/C*/G*/AA

Others

P *

P **

OR (95% CI)

CGI (N = 56)

     

Present: absent

14 (58): 10 (42)

15 (47): 17 (53)

0.115

0.429

1.6 (0.5-4.6)

Atrophy (N = 56)

     

Present: absent

17 (71): 7 (29)

21 (66): 11 (34)

0.932

0.778

1.3 (0.4-4.0)

SPEM (N = 48)

     

Present: absent

18 (82): 4 (18)

12 (46): 14 (54)

0.010

0.016

5.3 (1.4-19.8)

IM (N = 56)

     

Present: absent

4 (17): 20 (83)

6 (19): 26 (81)

0.831

1.000

0.9 (0.2-3.5)

  1. CGI: corpus predominant gastritis index. SPEM: spasmolytic polypeptide-expressing metaplasia. IM: intestinal metaplasia. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.