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Table 3 The difference of the H. pylori-related histological features between the children of gastric cancer patients with and without the risk allele genotypes as ITGA5-1160 T-carrier/ITGB1-1949 A-carrier/ITGB1+31804 C-carrier & COX-2-1195 G-carrier/IL10-592 AA

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Risks N (%) Pathology ITGA5 -1160/ ITGB1 -1949/ ITGB1 +31804/ COX-2 -1195/ IL10 -592 as T*/A*/C*/G*/AA Others P * P ** OR (95% CI)
CGI (N = 56)      
Present: absent 14 (58): 10 (42) 15 (47): 17 (53) 0.115 0.429 1.6 (0.5-4.6)
Atrophy (N = 56)      
Present: absent 17 (71): 7 (29) 21 (66): 11 (34) 0.932 0.778 1.3 (0.4-4.0)
SPEM (N = 48)      
Present: absent 18 (82): 4 (18) 12 (46): 14 (54) 0.010 0.016 5.3 (1.4-19.8)
IM (N = 56)      
Present: absent 4 (17): 20 (83) 6 (19): 26 (81) 0.831 1.000 0.9 (0.2-3.5)
  1. CGI: corpus predominant gastritis index. SPEM: spasmolytic polypeptide-expressing metaplasia. IM: intestinal metaplasia. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.