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Table 4 The differences of the single nucleotide polymorphisms in the RUNX3 , and TFF2 genes between children of gastric cancer patients with (N = 31) or without (N = 18) SPEM

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Parameters N (%) SPEM (+) SPEM (-) P * P ** OR (95% CI)
Age (yr) 39.9 ± 7.7 38.2 ± 11.3 0.312   
Gender (F: M) 20 (65): 11 (35) 7 (39): 11 (61) 0.092 0.136 2.9 (0.9 - 9.5)
RUNX3      
RUNX3 -18508 (N = 29) (N = 17)    
  C-carrier: GG 21 (72): 8 (28) 12 (71): 5 (29) 0.897 1.000 1.1 (0.3 - 4.1)
RUNX3 -1714 (N = 31) (N = 18)    
  A-carrier: CC 16 (52): 15 (48) 4 (22): 14 (78) 0.044 0.067 3.7 (1.0 - 13.9)
RUNX3 -1582 (N = 30) (N = 18)    
  T-carrier: CC 16 (53): 14 (47) 5 (28): 13 (72) 0.085 0.137 3.0 (0.8 - 10.4)
RUNX -1166 (N = 31) (N = 18)    
  C-carrier: TT 16 (52): 15 (48) 4 (22): 14 (78) 0.044 0.070 3.7 (1.0 - 13.9)
RUNX3 +492 (N = 30) (N = 18)    
  A-carrier: TT 16 (53): 14 (47) 4 (22): 14 (78) 0.035 0.042 4.0 (1.1 - 15.0)
RUNX3 +73375 (N = 30) (N = 18)    
  C-carrier: AA 21 (70): 9 (30) 14 (78): 4 (22) 0.613 0.741 0.7 (0.2 - 2.6)
TFF2      
TFF2 -1373 (N = 30) (N = 18)    
  C-carrier: TT 30 (100): 0 (0) 17 (94): 1 (6) 0.206 0.377 2.6 (0.8 - 9.2)
TFF2 -503 (N = 30) (N = 18)    
  AA: G-carrier 23 (77): 7 (23) 10 (56): 8 (44) 0.127 0.194 2.6 (0.7 - 9.2)
TFF2 -308 (N = 30) (N = 18)    
  CC: A-carrier 18 (60): 12 (40) 5 (28): 13 (72) 0.022 0.041 3.9 (1.1-13.8)
TFF2 +4649 (N = 30) (N = 18)    
  G-carrier: AA 26 (87): 4 (13) 17 (94): 1 (6) 0.419 0.637 0.4 (0.1-3.7)
RUNX3+492/TFF2-308      
 A-carrier/CC      
  2R 7 (23) 1 (6) 0.001 0.009 23.3 (2.0 - 273.3)
  1R 20 (67) 7 (39) 0.001 0.004 9.5 (2.0 - 44.9)
  0R 3 (10) 10 (56)    1
  2R+1R:0R 27 (90): 3 (10) 8 (44): 10 (56) 3×10-4 0.001 11.3 (2.5 - 51.0)
  1. SPEM: Spasmolytic polypeptide-expressing metaplasia; SNPs: single nucleotide polymorphisms. 2R: the presence of 2 predisposing SNPs with risk alleles. 1R: the presence of 1 predisposing SNP with risk allele. 0R: no any predisposing SNPs with risk alleles. *P value by mixed effect model; **P value by permutation test.