|
Predisposing SNPs
|
Risk SNPs N (%)
|
SPEM (+)
|
SPEM (−)
|
P
*
|
P
**
|
OR (95% CI)
|
|---|
|
ITGA5-1160/ITGB1-
|
2R: 1R: 0R
|
16 (53): 13 (43): 1 (3)
|
1 (6): 10 (56): 7 (39)
|
<1×10−4
| | |
|
1949/ITGB1+31804/COX-2-1195/IL10-592
|
2R: 1R+ 0R
|
16 (53): 14 (47)
|
1 (6): 17 (94)
|
5×104
|
0.001
|
19.4 (2.3-165.2)
|
|
as T*/A*/C*/G*/AA
| | | | | | |
| |
2R+ 1R: 0R
|
29 (97): 1 (3)
|
11 (61): 7 (39)
|
5×10−4
|
0.003
|
18.5 (2.0-167.8)
|
|
with or without
| | | | | | |
| |
2R
|
16 (53)
|
1 (6)
|
1×10−4
|
1×10−4
|
112.0 (6.1-2057.3)
|
|
RUNX3+492/TFF2-308
|
1R
|
13 (43)
|
10 (56)
|
0.045
|
0.0518
|
9.1 (1.0-86.5)
|
|
as A*/CC
|
0R
|
1 (3)
|
7 (39)
| | |
1
|
- SPEM: spasmolytic polypeptide-expressing metaplasia. SNPs: single nucleotide polymorphisms. 2R: the presence of 2 predisposing SNPs with risk alleles. 1R: the presence of 1 predisposing SNPs with risk allele. 0R: no any predisposing SNPs with risk alleles. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.
