Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Table 5 The risk of SPEM increases stepwise for ITGA5 -1160 T-carrier, ITGB1 -1949 A-carrier, ITGB1 +31804 C-carrier, COX-2 -1195 G-carrier, and IL10 -592 AA to combine with RUNX3 +492 as A-carrier & TFF2 -308 as CC in the children of gastric cancer patients

Predisposing SNPs	Risk SNPs N (%)	SPEM (+)	SPEM (−)	P *	P **	OR (95% CI)
ITGA5-1160/ITGB1-	2R: 1R: 0R	16 (53): 13 (43): 1 (3)	1 (6): 10 (56): 7 (39)	<1×10⁻⁴
1949/ITGB1+31804/COX-2-1195/IL10-592	2R: 1R+ 0R	16 (53): 14 (47)	1 (6): 17 (94)	5×10⁴	0.001	19.4 (2.3-165.2)
as T/A/C/G/AA
	2R+ 1R: 0R	29 (97): 1 (3)	11 (61): 7 (39)	5×10⁻⁴	0.003	18.5 (2.0-167.8)
with or without
	2R	16 (53)	1 (6)	1×10⁻⁴	1×10⁻⁴	112.0 (6.1-2057.3)
RUNX3+492/TFF2-308	1R	13 (43)	10 (56)	0.045	0.0518	9.1 (1.0-86.5)
as A*/CC	0R	1 (3)	7 (39)			1

SPEM: spasmolytic polypeptide-expressing metaplasia. SNPs: single nucleotide polymorphisms. 2R: the presence of 2 predisposing SNPs with risk alleles. 1R: the presence of 1 predisposing SNPs with risk allele. 0R: no any predisposing SNPs with risk alleles. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.