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Table 5 The risk of SPEM increases stepwise for ITGA5 -1160 T-carrier, ITGB1 -1949 A-carrier, ITGB1 +31804 C-carrier, COX-2 -1195 G-carrier, and IL10 -592 AA to combine with RUNX3 +492 as A-carrier & TFF2 -308 as CC in the children of gastric cancer patients

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Predisposing SNPs

Risk SNPs N (%)

SPEM (+)

SPEM (−)

P *

P **

OR (95% CI)

ITGA5-1160/ITGB1-

2R: 1R: 0R

16 (53): 13 (43): 1 (3)

1 (6): 10 (56): 7 (39)

<1×10−4

  

1949/ITGB1+31804/COX-2-1195/IL10-592

2R: 1R+ 0R

16 (53): 14 (47)

1 (6): 17 (94)

5×104

0.001

19.4 (2.3-165.2)

as T*/A*/C*/G*/AA

      
 

2R+ 1R: 0R

29 (97): 1 (3)

11 (61): 7 (39)

5×10−4

0.003

18.5 (2.0-167.8)

 with or without

      
 

2R

16 (53)

1 (6)

1×10−4

1×10−4

112.0 (6.1-2057.3)

RUNX3+492/TFF2-308

1R

13 (43)

10 (56)

0.045

0.0518

9.1 (1.0-86.5)

as A*/CC

0R

1 (3)

7 (39)

  

1

  1. SPEM: spasmolytic polypeptide-expressing metaplasia. SNPs: single nucleotide polymorphisms. 2R: the presence of 2 predisposing SNPs with risk alleles. 1R: the presence of 1 predisposing SNPs with risk allele. 0R: no any predisposing SNPs with risk alleles. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.
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Journal of Biomedical Science

ISSN: 1423-0127