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Table 5 The risk of SPEM increases stepwise for ITGA5 -1160 T-carrier, ITGB1 -1949 A-carrier, ITGB1 +31804 C-carrier, COX-2 -1195 G-carrier, and IL10 -592 AA to combine with RUNX3 +492 as A-carrier & TFF2 -308 as CC in the children of gastric cancer patients

From: Genomic single nucleotide polymorphisms in the offspring of gastric cancer patients predispose to spasmolytic polypeptide-expressing metaplasia after H. pylori infection

Predisposing SNPs Risk SNPs N (%) SPEM (+) SPEM (−) P * P ** OR (95% CI)
ITGA5-1160/ITGB1- 2R: 1R: 0R 16 (53): 13 (43): 1 (3) 1 (6): 10 (56): 7 (39) <1×10−4   
1949/ITGB1+31804/COX-2-1195/IL10-592 2R: 1R+ 0R 16 (53): 14 (47) 1 (6): 17 (94) 5×104 0.001 19.4 (2.3-165.2)
as T*/A*/C*/G*/AA       
  2R+ 1R: 0R 29 (97): 1 (3) 11 (61): 7 (39) 5×10−4 0.003 18.5 (2.0-167.8)
 with or without       
  2R 16 (53) 1 (6) 1×10−4 1×10−4 112.0 (6.1-2057.3)
RUNX3+492/TFF2-308 1R 13 (43) 10 (56) 0.045 0.0518 9.1 (1.0-86.5)
as A*/CC 0R 1 (3) 7 (39)    1
  1. SPEM: spasmolytic polypeptide-expressing metaplasia. SNPs: single nucleotide polymorphisms. 2R: the presence of 2 predisposing SNPs with risk alleles. 1R: the presence of 1 predisposing SNPs with risk allele. 0R: no any predisposing SNPs with risk alleles. *Indicated the carrier of the specific allele in SNPs. *P value by mixed effect model; **P value by permutation test.