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Table 2 Association analysis between the NTRK2 polymorphisms and eGFR and SrCr

From: Evaluation of Neurotrophic Tyrosine Receptor Kinase 2 (NTRK2) as a positional candidate gene for variation in estimated Glomerular Filtration Rate (eGFR) in Mexican American participants of San Antonio Family Heart Study

SNPs

SNP ID

Location on NTRK2

Chromosome position (GRCh37/hg19)

Major / Minor allele (%) in Europeans (HapMap)

Major / Minor allele (%) in Mexican Americans

eGFR ( P values)*

Serum creatinine (SrCr) ( P values)*

1

rs11140800

3′UTR

87508137

A(52) / C (48)

A(52) / C (48)

0.184

0.163

2

rs995861

3′UTR

87541642

T (67) / C (33)

T (69) / C (31)

0.298

0.375

3

rs1036915

3′UTR

87437849

A (64) / G (36)

A (62) / G (38)

0.017

0.040

4

rs1187274

Intron-14

87419789

G (58) / C (42)

G (60) / C (40)

0.017

0.038

5

rs1187350

Intron-4

87295237

A (55) / G (45)

A (60) / G (40)

0.408

0.598

6

rs1187352

Intron-4

87293457

C (64) / T (36)

C (78) / T (22)

0.975

0.888

7

rs1867283

3′UTR

87450766

A (51) / G (49)

A (53) / G (47)

0.679

0.521

8

rs2083828

3′UTR

87447045

C (52) / A (48)

C (56) / A (44)

0.126

0.128

9

rs2808707

3′UTR

87558294

G (58) / T (42)

G (54) / T (46)

0.079

0.076

10

rs7019555

3′UTR

87614445

A (71) / G (29)

A (76) / G (24)

0.255

0.551

11

rs10746747

Intron-11

87354637

T (70) / A (30)

T (66) / A (34)

0.960

0.965

12

rs10780690

3′UTR

87478172

G (52) / T (48)

G (54) / T (46)

0.966

0.792

  1. *eGFR (estimated Glomerular filtration rate by MDRD equation) and SrCr (serum creatinine) were adjusted for the effects of age, sex, diabetes, diabetes duration, systolic blood pressure, blood pressure medication.