A strain-independent method to induce progressive and lethal pneumococcal pneumonia in neutropenic mice

Table 1 Capsular serotypes, antibiotic susceptibility patterns and in vivo virulence of the seven pneumococcal strains included in the study

*S. pneumoniae* strain	Capsular serotype	Pattern of susceptibility to antibiotics	Mouse virulence*
INS-E611	6B	DRSP (PEN-R, CRO-I, SXT-R)	4+
INS-E674	14	DRSP (PEN-R, CRO-I, SXT-R)	1+
INS-E676	14	DRSP (PEN-I, SXT-R)	1+
INS-E678	14	DRSP (PEN-I, SXT-R)	1+
INS-E683	9 V	DRSP (PEN-I, SXT-R)	2+
INS-E684	14	PNSSP (PEN-I)	2+
ATCC 49619	19 F	PNSSP (PEN-I)	3+

Abbreviations. INS: Instituto Nacional de Salud; CSF: Cerebro-Spinal fluid; DRSP: Drug-Resistant S. pneumoniae; PNSSP: Penicillin-Non-Susceptible S. pneumoniae; PEN: Penicillin; CRO: Ceftriaxone; SXT: Trimethoprim-sulfamethoxazole; CHL: Chloramphenicol; R: Resistant; I: Intermediate; *Mouse virulence of 4+ means that mice died during the assay, 3+: mice with systemic illness, 2+: mice with localized sickness and 1+: mice without clinical signs of disease.

ISSN: 1423-0127