| Strain of Penicillin Non Susceptible Streptococcus pneumoniae | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Parameter | ATCC 49619 | INS-E611 | INS-E674 | INS-E676* | INS-E678* | INS-E683 | INS-E684 | |||||||
Inoculum preparation: Todd Hewitt broth (THB) without or with mucin | THB | Mucin + THB | THB | Mucin + THB | THB | Mucin + THB | THB | Mucin + THB | THB | Mucin + THB | THB | Mucin + THB | THB | Mucin + THB |
Inoculum (mean, log 10 CFU/mouse) | 7.12 | 6.34 | 6.95 | 6.78 | 6.46 | 6.79 | 6.28 | 6.20 | 6.53 | 6.53 | 6.71 | 6.61 | 7.00 | 6.25 |
Time to nadir (h) | 14 | 14 | 14 | 14 | 14 | 14 | ** | ** | ** | ** | 14 | 14 | 14 | 14 |
Time to zenith (h) | 42 | 38 | 36 | 38 | 48 | 38 | *** | *** | *** | *** | 36 | 38 | 48 | 38 |
Bacterial count at nadir (mean log 10 CFU/mouse ± SD) | 5.82 ± 0.09 | 6.32 ± 0.52 | 5.43 ± 0.39 | 5.35 ± 0.53 | 6.52 ± 0.65 | 7.34 ± 0.43 | 4.30 ± 0.36 | 3.97 ± 0.43 | 4.93 ± 0.06 | 6.02 ± 0.13 | 4.90 ± 0.17 | 5.70 ± 0.39 | 7.01 ± 0.72 | 6.73 ± 0.74 |
Bacterial count at zenith (mean log 10 CFU/mouse ± SD) | 8.02 ± 0.05 | 6.79 ± 0.44 | 7.58 ± 0.35 | 9.26 ± 0.19 | 8.70 ± 0.51 | 9.15 ± 0.34 | 5.09 ± 0.56 | 7.51 ± 0.18 | 6.68 ± 0.04 | 8.67 ± 0.28 | 7.77 ± 0.53 | 8.91 ± 0.75 | 9.59 ± 0.53 | 9.01 ± 0.52 |
Growth from nadir to zenith (mean) | 2.19 | 0.47 | 2.15 | 3.91 | 2.18 | 1.63 | --- | --- | --- | --- | 2.87 | 3.21 | 2.58 | 2.28 |
Growth from hour 14 to 38 (mean) | 1.24 | 0.47 | −0.43 | 3.91 | 1.89 | 1.63 | 0.79 | 3.54 | 1.75 | 2.65 | 1.83 | 3.21 | 1.94 | 2.28 |
Mouse Lethality (%) | 0 | 100 | 0 | 100 | 67 | 100 | 0 | 100 | 0 | 100 | 0 | 100 | 100 | 100 |
Time to death (mean, h) | All alive | 64 | All alive | 52 | 56 | 52 | All alive | 44 | All alive | 44 | All alive | 59 | 61 | 51 |
Bacterial count after death from pneumonia and sepsis (mean ± SD) | All alive | 8.21 ± 0.51 | All alive | 8.37 ± 0.39 | 9.52 ± 0.01 | 9.00 ± 0.30 | All alive | 7.89 ± 0.43 | All alive | 8.92 ± 0.05 | All alive | 8.52 ± 0.62 | 8.22 ± 0.38 | 8.76 ± 0.04 |