Skip to main content
Figure 6 | Journal of Biomedical Science

Figure 6

From: Beneficial effects of co-treatment with dextromethorphan on prenatally methadone-exposed offspring

Figure 6

Changes of LTP and LTD in the prenatal methadone- or DM-exposed offspring. Prenatal methadone did not change the hippocampal LTP or LTD in p14-p21 rats. Time courses of normalized slopes of fEPSPs during (A) LTP and (B) LTD experiments are shown. A high-frequency stimulation (HFS) protocol (A) or a low-frequency stimulation (LFS) protocol (B) was applied at 0 min (arrow) to hippocampal slice of p14-p21 offspring born from control (black circle, n ≥ 8) or methadone (hollow circle, n ≥ 7) treated maternal rats. Representative traces of fEPSP from one control slice before HFS (1) and 55 min after HFS (2) are shown in the top middle of (A), and another representative traces of fEPSP from one control before (1) and 60 min after (2) LFS are shown in the top middle of (B). Scale bar, 100 μV, 10 ms.

Back to article page