Figure 1From: The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient miceSHP deficiency causes non-responsiveness to antidiabetic effect of TZDs. (A, B) Serum glucose (A) and insulin (B) levels under fasting conditions. 7ā8 week-old male ob/ob and ob/ob;Shp ā/ā mice were treated with control (open bars) or troglitazone (filled bars) for 2Ā weeks. (C) Glucose tolerance tests. Intraperitoneal glucose tolerance tests were performed on ob/ob and ob/ob;Shp ā/ā mice treated with control (open symbols) or troglitazone (filled symbols) for 2Ā weeks. nā=ā4ā5 per group. Data are meanāĀ±āSEM. *Pā<ā0.05, **Pā<ā0.01, ***Pā<ā0.001 for differences between control and troglitazone-treated ob/ob mice. #Pā<ā0.01 for differences between ob/ob;Shp ā/ā (with no effect of troglitazone treatment) and control-treated ob/ob mice.Back to article page