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Figure 1 | Journal of Biomedical Science

Figure 1

From: The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice

Figure 1

SHP deficiency causes non-responsiveness to antidiabetic effect of TZDs. (A, B) Serum glucose (A) and insulin (B) levels under fasting conditions. 7ā€“8 week-old male ob/ob and ob/ob;Shp āˆ’/āˆ’ mice were treated with control (open bars) or troglitazone (filled bars) for 2Ā weeks. (C) Glucose tolerance tests. Intraperitoneal glucose tolerance tests were performed on ob/ob and ob/ob;Shp āˆ’/āˆ’ mice treated with control (open symbols) or troglitazone (filled symbols) for 2Ā weeks. nā€‰=ā€‰4ā€“5 per group. Data are meanā€‰Ā±ā€‰SEM. *Pā€‰<ā€‰0.05, **Pā€‰<ā€‰0.01, ***Pā€‰<ā€‰0.001 for differences between control and troglitazone-treated ob/ob mice. #Pā€‰<ā€‰0.01 for differences between ob/ob;Shp āˆ’/āˆ’ (with no effect of troglitazone treatment) and control-treated ob/ob mice.

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