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Figure 3 | Journal of Biomedical Science

Figure 3

From: The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient mice

Figure 3

Expression of lipogenic genes was downregulated by SHP deficiency in ob/ob mice liver. ResultsĀ in panels A and B are liver mRNA levels for control (open bars) and troglitazone-treated (filled bars) mice after 2Ā weeks of treatment. Data are expressed as relative fold change after normalized to 36B4 and are meanā€‰Ā±ā€‰SEM (nā€‰=ā€‰4ā€“5 per group). By two-way ANOVA, the genotype effect (ob/ob and ob/ob;Shp āˆ’/āˆ’) is significant (Pā€‰<ā€‰0.05) for all except PPARĪ³1Ā in panel A. The treatment effect and genotypeā€‰Ć—ā€‰treatment interaction is significant for CD36, aP2, FAS, ACC1 and PEPCKĀ in panel B.

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