Expression of lipogenic genes was downregulated by SHP deficiency in ob/ob mice liver. Results in panels A and B are liver mRNA levels for control (open bars) and troglitazone-treated (filled bars) mice after 2 weeks of treatment. Data are expressed as relative fold change after normalized to 36B4 and are mean ± SEM (n = 4–5 per group). By two-way ANOVA, the genotype effect (ob/ob and ob/ob;Shp
−/−) is significant (P < 0.05) for all except PPARγ1 in panel A. The treatment effect and genotype × treatment interaction is significant for CD36, aP2, FAS, ACC1 and PEPCK in panel B.