SHP deficiency affects TZD-responsive gene expression in adipose tissue of ob/ob mice. Results are adipose mRNA levels for control (open bars) and troglitazone-treated (filled bars) mice after 2 weeks of treatment. Data are expressed as relative fold change after normalized to 36B4 and are mean ± SEM (n = 4–5 per group). By two-way ANOVA, the genotype and treatment effect is significant (P < 0.05) for PPARγ2 and resistin (treatment effect for CD36, P = 0.06). The genotype × treatment interaction is significant only for resistin. By two-tailed t test, P < 0.05 for differences in adiponectin expression between control and troglitazone-treated ob/ob mice.