Figure 4From: The orphan nuclear receptor small heterodimer partner is required for thiazolidinedione effects in leptin-deficient miceSHP deficiency affects TZD-responsive gene expression in adipose tissue of ob/ob mice. Results are adipose mRNA levels for control (open bars) and troglitazone-treated (filled bars) mice after 2Ā weeks of treatment. Data are expressed as relative fold change after normalized to 36B4 and are meanāĀ±āSEM (nā=ā4ā5 per group). By two-way ANOVA, the genotype and treatment effect is significant (Pā<ā0.05) for PPARĪ³2 and resistin (treatment effect for CD36, Pā=ā0.06). The genotypeāĆātreatment interaction is significant only for resistin. By two-tailed t test, Pā<ā0.05 for differences in adiponectin expression between control and troglitazone-treated ob/ob mice.Back to article page