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Table 1 Antiviral activity profile of 3b against DENV serotypes

From: Antiviral activity of an N-allyl acridone against dengue virus

DENV serotype

EC 50 (μM) a

SI b

DENV-1

26.7 ± 1.8

>37.3

DENV-2

13.5 ± 0.9

>74.1

DENV-3

27.1 ± 2.1

>36.9

DENV-4

12.5 ± 0.8

>80.0

  1. aEffective concentration 50%: compound concentration required to reduce virus yields at 48 h p.i. by 50%. Values are the mean from triplicate independent tests ± standard deviation.
  2. bSelectivity index: ratio CC50/EC50. The CC50 for 3b is > 1000 μM.
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Journal of Biomedical Science

ISSN: 1423-0127