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Table 1 Antiviral activity profile of 3b against DENV serotypes

From: Antiviral activity of an N-allyl acridone against dengue virus

DENV serotype EC 50 (μM) a SI b
DENV-1 26.7 ± 1.8 >37.3
DENV-2 13.5 ± 0.9 >74.1
DENV-3 27.1 ± 2.1 >36.9
DENV-4 12.5 ± 0.8 >80.0
  1. aEffective concentration 50%: compound concentration required to reduce virus yields at 48 h p.i. by 50%. Values are the mean from triplicate independent tests ± standard deviation.
  2. bSelectivity index: ratio CC50/EC50. The CC50 for 3b is > 1000 μM.