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Table 3 Analysis of variance was conducted on the global methylation results with disease group as the factor variable, and the results were verified with Bartlett’s test. A Bonferroni correction shows that the SLE and SSc groups were significantly different from the controls but not significantly different from each other, although there was a trend towards lower values in the SSc group compared to the SLE group

From: DNA methylation similarities in genes of black South Africans with systemic lupus erythematosus and systemic sclerosis

Study groups

Global methylation %

Mean

Standard deviation (SD)

Range

Controls

33.9

11

11-53

SLE

22.2

5

15 – 33

SSc

17.7

5

3.8 - 24

Study groups comparison

 

(mean difference) P value

 

Controls

SLE

SLE

(−11) p = 0.00

-

SSc

(− 16) p = 0.00

(−4) p = 0.068