Fig. 6

The summary of naloxone, naloxonazine, naltrindole and nor-binaltorphimine on EA’s effect on sleep in rats with focal epilepsy. The bars from the left to the right in each panel represent the data acquired from the PFS + EA + pilocarpine group, the naloxone + EA + pilocarpine group, the naloxonazine + EA + pilocarpine group, the naltrindole + EA + pilocarpine and the nor-binaltorphimine + EA + pilocarpine group. Panels a and b represent the percentage of time spent in NREM sleep during the 12-h dark period and the subsequent 12-h light period, respectively. Panels c and d indicate the percentage of time spent in REM sleep during the 12-h dark period and the subsequent 12-h light period, respectively. **: p < 0.05 when comparing the values between two groups