Fig. 2
Effects of the 5-HT receptor antagonists on 5-HT-induced coronary responses in isolated rat hearts. a Typical traces of 5-HT-induced coronary flow responses in the presence of vehicle, SB269970, or the combination of SB269970 and R96544. b In isolated rat heart, 5-HT induced coronary flow increases, but in 5-HT7 receptor antagonist SB269970 0.3 μM-treated hearts, 5-HT caused decreases in coronary flow. In hearts treated with SB269970 0.3 μM and the 5-HT2A antagonist R96544 0.3 μM, 5-HT did not elicit a coronary response. c The 5-HT7 receptor agonist 5-CT elicited coronary flow increases, and this effect was blocked by SB269970 0.3 μM. Data were expressed as the mean ± SD. #P < 0.05, ##P < 0.01, and ###P < 0.005 compared to the treatment; ƗƗƗP < 0.005 compared to the control group (one-way ANOVA followed by Bonferroni post-test); $$$P < 0.005 compared to the SB269970-treated group; &P < 0.05, &&&P < 0.005 between the compared groups (2-ways ANOVA followed by Bonferroni post-test)