Fig. 2From: Complement and macrophage crosstalk during process of angiogenesis in tumor progressionMacrophage polarization: Model illustrates M1 and M2 macrophage mediated angiogenesis in tumor development. M2 macrophages promote tumor growth through the release of TGF-β, IL-10, IL-17, IL-23, VEGF, and FGF2 required for tumor growth. In contrast, M1 macrophages suppress tumor growth through the release IFN-γ IL-12, and TNF-αBack to article page