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Fig. 4 | Journal of Biomedical Science

Fig. 4

From: Overexpression of mutant HSP27 causes axonal neuropathy in mice

Fig. 4

Aberration in myelination was observed in HSP27-S135F mice. Toluidine blue staining showed normal myelination in normal mice (a) and demyelination in HSP27-S135F mice (b). Scale bar = 20 μM. c. Distribution of diameter of myelinated axon demonstrated that the proportion of large (>15 μm) myelinated fibers are reduced in HSP27-S135F mice. **, p < 0.01. Electron microscopy demonstrated normal pattern in normal mice (d) and abnormal myelination in transgenic mice (e-g). Magnifications: (d) and (e), x 1000; (f) and (g), x 4000

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