Fig. 1From: Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampusIntraperitoneal LPS infusion induces peripheral inflammation which is not affected by intracerebroventricular infusion of NS398 or tempol. Plasma levels of interleukin-1β (IL-1β, a), IL-6 (b), and tumor necrosis factor-α (TNF-α, c) measured on day 7 after intraperitoneal infusion via an osmotic minipump of saline or LPS (2.5 mg/kg/day) for 7 days alone or with additional intracerebroventricular infusion of NS398 (5 μg/μl/h, dissolved in 1 % DMSO), tempol (2.5 μg/μl/h, dissolved in saline), or the corresponding vehicle. Values are mean ± SEM, n = 10–12 rats per group. *P <0.05 vs. saline-treated group in the post hoc Scheffé multiple-range testBack to article page