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Fig. 1 | Journal of Biomedical Science

Fig. 1

From: Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Fig. 1

Intraperitoneal LPS infusion induces peripheral inflammation which is not affected by intracerebroventricular infusion of NS398 or tempol. Plasma levels of interleukin-1β (IL-1β, a), IL-6 (b), and tumor necrosis factor-α (TNF-α, c) measured on day 7 after intraperitoneal infusion via an osmotic minipump of saline or LPS (2.5 mg/kg/day) for 7 days alone or with additional intracerebroventricular infusion of NS398 (5 μg/μl/h, dissolved in 1 % DMSO), tempol (2.5 μg/μl/h, dissolved in saline), or the corresponding vehicle. Values are mean ± SEM, n = 10–12 rats per group. *P <0.05 vs. saline-treated group in the post hoc Scheffé multiple-range test

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