Fig. 4
The COX-2-dependent upregulations of the NADPH oxidase subunits in the hippocampus after intraperitoneal LPS infusion. Representative gels (insert) and densitometric analysis of results from Western blot showing changes in expression of gp91phox (a), p47phox (b) and p67phox (c) in the hippocampus, measured on day 7 after intraperitoneal infusion via an osmotic minipump of saline or LPS (2.5 mg/kg/day) for 7 days alone or with additional intracerebroventricular infusion of NS398 (5 μg/μl/h, dissolved in 1 % DMSO), tempol (2.5 μg/μl/h, dissolved in saline) or the corresponding vehicle. Values are mean ± SEM, n = 8–10 rats per group. *P <0.05 vs. saline-treated group; #P <0.05 vs. LPS-treated group in the post hoc Scheffé multiple-range test