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Fig. 7 | Journal of Biomedical Science

Fig. 7

From: Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Fig. 7

COX-2-dependent and redox-sensitive increase in seizure susceptibility after intraperitoneal LPS infusion. Time-course changes in kainic acid-induced seizure stage (a), total seizure activity (stages) (b) and seizure onset time to stage 3 (c) measured on day 7 after intraperitoneal infusion via an osmotic minipump of saline or LPS (2.5 mg/kg/day) for 7 days alone or with additional intracerebroventricular infusion of NS398 (5 μg/μl/h, dissolved in 1 % DMSO), tempol (2.5 μg/μl/h, dissolved in saline) or the corresponding vehicle. Values are mean ± SEM, n = 8-10 rats per group. *P <0.05 vs. saline-treated group; #P <0.05 vs. LPS-treated group in the post hoc Scheffé multiple-range test

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