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Table 1 Effect of daily bolus injection of NS398 (10 mg/kg, i.p.) on the increases in plasma proinflammatory cytokine levels following intraperitoneal infusion of Escherichia coli lipopolysaccharide (LPS, 2.5 mg/kg/day) for 7 days

From: Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Cytokines Treatment
(pg/ml) Saline LPS LPS + DMSO LPS + NS398
IL-1β 485 ± 62 1086 ± 135* 1226 ± 165* 637 ± 88**
IL-6 567 ± 83 1669 ± 231* 1450 ± 204* 709 ± 74**
TNF-α 68 ± 11 127 ± 22* 136 ± 24* 75 ± 18**
  1. Data are mean ± S.E.M., n = 6-8 animals per group
  2. * P < 0.05 versus saline group; ** P < 0.05 versus LPS group in the Scheffé multiple-range test
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