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Table 1 Effect of daily bolus injection of NS398 (10 mg/kg, i.p.) on the increases in plasma proinflammatory cytokine levels following intraperitoneal infusion of Escherichia coli lipopolysaccharide (LPS, 2.5 mg/kg/day) for 7 days

From: Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus

Cytokines

Treatment

(pg/ml)

Saline

LPS

LPS + DMSO

LPS + NS398

IL-1β

485 ± 62

1086 ± 135*

1226 ± 165*

637 ± 88**

IL-6

567 ± 83

1669 ± 231*

1450 ± 204*

709 ± 74**

TNF-α

68 ± 11

127 ± 22*

136 ± 24*

75 ± 18**

  1. Data are mean ± S.E.M., n = 6-8 animals per group
  2. * P < 0.05 versus saline group; ** P < 0.05 versus LPS group in the Scheffé multiple-range test